Pleiotropic mutations within two yeast mitochondrial cytochrome genes block mRNA processing.
نویسندگان
چکیده
The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants seem to lack a functional trans-acting RNA required for the processing of both messengers. In contrast, the oxi-3 mutants may act by producing an activity that inhibits specific steps.
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عنوان ژورنال:
- Cell
دوره 18 4 شماره
صفحات -
تاریخ انتشار 1979